Heterogeneity of the pregnancy-specific β1-glycoprotein (SP1)
✍ Scribed by S. Sørensen
- Book ID
- 115823792
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 922 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0009-8981
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Pregnancy-specific &glycoprotein was purified to 99% purity by sequential chromatography on carboxymethyl-cellulose (to remove other pregnancy-specific &-glycoprotein variants), Cibacron blue 3G-A-Matrex Gel, Procion turquoise MX-G-Matrex Gel, Procion red H-IBN-Matrex Gel, and rabbit anti-normal hum
Pregnancy-specific P,-glycoprotein, SP,, was measured in serum by competitive double antibody radioimmunoassay. Very low levels of SP, or SP,like activity were found in only 2 out of 85 sera from patients with cancer of the digestive tract, breast cancer, melanoma, and sarcoma, in 2 out of 11 sera f