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Is SP1 (pregnancy specific β1 glycoprotein) elevated in cancer patients?

✍ Scribed by E. Engvall; R. H. Yonemoto

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
284 KB
Volume
24
Category
Article
ISSN
0020-7136

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✦ Synopsis

Pregnancy-specific P,-glycoprotein, SP,, was measured in serum by competitive double antibody radioimmunoassay. Very low levels of SP, or SP,like activity were found in only 2 out of 85 sera from patients with cancer of the digestive tract, breast cancer, melanoma, and sarcoma, in 2 out of 11 sera from patients with infectious diseases, and in none out of 15 sera from non-pregnant healthy individuals. SP, thus does not seem t o be ectopically produced in vivo by the types of cancer studied, but is probably highly specific for the normal and malignant trophoblast.

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