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Heterocyclic analogs of the antihypertensive .beta.-adrenergic blocking agent (S)-2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine

โœ Scribed by Baldwin, John J.; Engelhardt, Edward L.; Hirschmann, Ralph; Ponticello, Gerald S.; Atkinson, Joseph G.; Wasson, Burton K.; Sweet, Charles S.; Scriabine, Alexander


Book ID
115538467
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
809 KB
Volume
23
Category
Article
ISSN
0022-2623

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GLC determination of S-2-(3-tert-butylam
โœ S. Vickers; C. A. H. Duncan ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 231 KB ๐Ÿ‘ 1 views

S-2-(3-tert-Butylamino-2-hydroxypropoxy)-3-cyanopyridine was recovered (approximately 90%) from human plasma and detected by conversion to a diheptafluorobutyryl derivative for electron-capture GLC. A homolog served as an internal standard. The method measures plasma drug concentrations at the 5-ng/