Synthesis of 2-chloro-5-hydroxynicotinonitrile: The required intermediate in the total synthesis of a hydroxylated metabolite of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine
โ Scribed by Gerald S. Ponticello; Edward L. Engelhardt; Mark B. Freedman; John J. Baldwin
- Book ID
- 112125975
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1980
- Tongue
- English
- Weight
- 279 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-152X
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๐ SIMILAR VOLUMES
S-[1-(2,3-Diaminophenoxy)]-3'-(N-t-butylamino)propan-2'-ol has been synthesized in three steps from 2,3-dinitro-phenol and the chiral auxiliary, S-glycidyl-3-nitrobenzenesulphonate, to provide a precursor for labelling S-(3'-t-butylamino-2'-hydroxypropoxy)-benzimidazol-2-one (S-CGP 12177) with the s
## Abstract 2โMethylisocitrate (=3โhydroxybutaneโ1,2,3โtricarboxylic acid) is an intermediate in the oxidation of propanoate to pyruvate (=2โoxopropanoate) __via__ the methylcitrate cycle in both bacteria and fungi (__Schemeโ 1__). Stereocontrolled syntheses of (2__R__,3__S__)โ and (2__S__,3__R__)โ2