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Heteroarylation of 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazole with N-(Ethoxycarbonyl)heteroaromatic Salts

✍ Scribed by Susan Shilcrat; Ivan Lantos; Michael Mcguire; Lendon Pridgen; Louisa Davis; Drake Eggleston; David Staiger; Lee Webb


Book ID
112130822
Publisher
Journal of Heterocyclic Chemistry
Year
1993
Tongue
English
Weight
533 KB
Volume
30
Category
Article
ISSN
0022-152X

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A facile approach to the synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b]thiazole was reported. A resin bound cyclic thiourea was formed by the treatment of a resin bound diamine with 1,1'-thiocarbonyldiimidazole, and then reacted with a Ξ±-haloketone to generate a resin bound isothiourea.

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## Abstract magnified image A novel method for the preparation of 2,3‐dihydroimidazo[2,1‐__b__]thiazole **9** by iodination and subsequent cyclization of the easily available __N__‐allylimidazoline‐2‐thiones **5**, is described. Selected transformations of the iodomethyl derivatives **9**, leading