Herpes simplex virus persistence in mouse neuroblastoma (C 1300) cell cultures: Role of interferon
โ Scribed by G. J. Dawson; S. L. Mowshowitz; R. Cohen; Teresita S. Elizan
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 489 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1435-1463
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In this study, the effect of the synthetic glucocorticoid hormone dexamethasone (DXM) on HSV replication was studied in a DXM receptor-positive mouse neuroblastoma (NB) cell line. In cells treated with 10-7M DXM and then infected with HSV, there was a statistically significant 9-1 8-fold increase in
Monolayers of NB41A3 (MNB) cells were exposed to pharmacologic doses of dexamethasone (DXM). After 24-h, the cells were infected with herpes simplex virus type 1 (HSV-I) at a multiplicity of infection (m.0.i.) = 0.1. After every 24-h period, extracellular and intracellular virus aliquots were collec