Heritable translocation and dominant-lethal mutation induction with ethylene oxide in mice
โ Scribed by W.M. Generoso; K.T. Cain; M. Krishna; C.W. Sheu; R.M. Gryder
- Book ID
- 113191861
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 627 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0027-5107
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Male mice were subjected to repeated inhalation exposures to different concentrations (1 65, 204, 250, or 300 ppm) of ethylene oxide (EtO) during an 8.5-week period. Transmitted clastogenic effects of these exposures were measured in terms of induction of dominant lethal mutations and heritable tran
Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant-lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubat