Hereditary spastic paraplegia and amyotrophy associated with a novel locus on chromosome 19
✍ Scribed by K. G. Meilleur; M. Traoré; M. Sangaré; A. Britton; G. Landouré; S. Coulibaly; B. Niaré; F. Mochel; A. La Pean; I. Rafferty; C. Watts; D. Shriner; M. T. Littleton-Kearney; C. Blackstone; A. Singleton; K. H. Fischbeck
- Book ID
- 106257325
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 246 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1364-6745
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## Abstract Spastic paraplegias (HSPs) and dystonias (DYTs) typically localize to different neuroanatomic systems. We report clinical and genetic data from large Ohio kindred with autosomal dominant (AD) HSP and DYT. Single and multipoint linkage using microsatellite and single nucleotide polymorph
Hereditary spastic paraplegia is a clinically and genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. Seven loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have already been mapped on chromosomes 14q, 2p, 15q, 8p, 12q, 19q, and 2q. W