Muscle satellite cell activation following injury is essential for muscle repair, and hepatocyte growth factor/scatter factor (HGF) was the first growth factor shown to be able to stimulate activation and early division of adult satellite cells in culture and in muscle tissue. In addition, HGF was s
Hepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro
โ Scribed by Ronald E. Allen; Shannon M. Sheehan; Richard G. Taylor; Teresa L. Kendall; Glenna M. Rice
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 600 KB
- Volume
- 165
- Category
- Article
- ISSN
- 0021-9541
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## Abstract When skeletal muscle is stretched or injured, satellite cells are activated to proliferate, and this process can be mediated by release of the active form of hepatocyte growth factor (HGF) from the extracellular matrix. The objective of these experiments was to determine whether the mec
We are reporting experiments that provide initial documentation of the action of TGF-beta on satellite cells. TGF-beta could be one of the important growth factors that act in concert to regulate the proliferation and differentiation of satellite cells in skeletal muscle. MATERIALS AND METHODS ##
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional polypeptide which acts as mitogen, motogen, or morphogen. In this study, we examined the effect of HGF/SF on human hair growth using organ and cell culture systems. HGF/SF was found to stimulate hair length and DNA synthesis in ha