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Hepatocellular carcinoma development requires hepatic stem cells with altered transforming growth factor and interleukin-6 signaling

✍ Scribed by Nicholas A. Shackel; Geoffrey W. McCaughan; Fiona J. Warner

Book ID: 102240068
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 165 KB
Volume: 47
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.22369

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✦ Synopsis

Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet functional interactions between specific signaling pathways in solid organ "cancer stem cells," such as those of the liver, remain elusive. We report that in regenerating human liver, two to four cells per 30,000-50,000 cells express stem cell proteins Stat3, Oct4, and Nanog, along with the prodifferentiation proteins TGF-beta-receptor type II (TBRII) and embryonic liver fodrin (ELF). Examination of human hepatocellular cancer (HCC) reveals cells that label with stem cell markers that have unexpectedly lost TBRII and ELF.

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