Hepatitis B virus X protein modulates the apoptosis of hepatoma cell line induced by TRAIL
β Scribed by Xiaohong Liang; Wensheng Sun; Lifen Gao; Chunhong Ma; Lihui Han; Youhai Chen
- Publisher
- Science in China Press (SCP)
- Year
- 2005
- Tongue
- English
- Weight
- 452 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1674-7305
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## Abstract Hepatitis B virus X protein (HBx) is essential for viral replication and plays an important role in viral pathogenesis. HBx transactivates many viral and cellular genes and participates in cellular signal transduction pathways, proliferation, and apoptosis. In the present study, we repo
## Abstract Hepatitis B virus (HBV) X protein (HBx) has been implicated in HBVβassociated carcinogenesis through activation of IΞΊB kinase (IKK)/nuclear factor kappa B (NFβΞΊB) signaling pathway. Besides activating NFβΞΊB in the cytoplasm, IKKΞ± was found in the nucleus to regulate gene expression epig
## Abstract We have recently reported that the naturally occurring spliced variant of Hepatitis B virus protein, HBSP, displayed proapoptotic activity through its BH3 domain. To investigate whether the BH3 domain in HBSP interacted with Bclβ2 family of proteins, HBSP and Bclβ2 family of proteins we