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Hepatitis B Virus Basal Core Promoter Mutation and DNA Load Correlate with Expression of Hepatitis B Core Antigen in Patients with Chronic Hepatitis B

✍ Scribed by Liu, Chun‐Jen; Jeng, Yung‐Ming; Chen, Chi‐Lin; Cheng, Huei‐Ru; Chen, Pei‐Jer; Chen, Ting‐Chi; Liu, Chen‐Hua; Lai, Ming‐Yang; Chen, Ding‐Shinn; Kao, Jia‐Horng


Book ID
123615397
Publisher
University of Chicago Press
Year
2009
Tongue
English
Weight
196 KB
Volume
199
Category
Article
ISSN
0022-1899

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The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer