The relationship between core promoter mutation of hepatitis B virus, viral load and hepatitis B e antigen status in chronic hepatitis B patients
β Scribed by Sohair K. Sayed; Mohammad A. kobeisy
- Book ID
- 116354890
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 251 KB
- Volume
- 276
- Category
- Article
- ISSN
- 0008-8749
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The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer
A commercial radioimmunoassay was adapted to detect serum Dane particle-associated HBeAg in patients whose sera contained the homologous antibody. HBeAg was released from Dane particles with guanidine HC1. Dane particles were separated from anti-HBe by gel-filtration (Sepharose 4B) and ultracentrif
## Abstract A study was conducted during a 1 year followβup to characterize the viral kinetics in hepatitis B e antigen (HBeAg)βpositive chronic hepatitis B and to develop a model of predicting the probability of spontaneous HBeAg seroconversion. Fiftyβseven patients with HBeAgβpositive chronic hep