𝔖 Bobbio Scriptorium
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Hepatitis B core antigen in serum during acute hepatitis B

✍ Scribed by L. Chemello; P. Pontisso; E. Schiavon; V. Thiers; G. Tagariello; Dr. A. Albert

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
313 KB
Volume
24
Category
Article
ISSN
0146-6615

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✦ Synopsis

Hepatitis B core antigen was measured in sera of patients with acute and chronic hepatitis B virus infection by a modified radioimmunoassay based on high molarity treatment of samples to avoid masking of antigen by homologous antibody. A good correlation between hepatitis B core antigen levels and serum HBV-DNA was observed in sera obtained during chronic infection. In contrast, acute phase sera were often HBcAg positive but HBV-DNA negative, particularly when obtained during maximum liver damage. Sequential studies in 5 patients with acute hepatitis B showed that HBcAg positivity persisted beside HBV-DNA clearance and was often enhanced at the time of maximum liver damage, suggesting release of antigen from infected hepatocytes undergoing immunolysis, even after termination of virus replication.

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