Humoral and cellular immune responses to hepatitis B vaccination in hepatitis B surface antigen-carrier children who cleared serum- hepatitis B surface antigen

✍ Scribed by H Hsu; M Chang; R Hsieh; Y Ni; W Chi

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 186 KB
• Volume: 24
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510240607

✦ Synopsis

Abbreviations: HBsAg, hepatitis B surface antigen; anti-HBs, hepatitis B surface antimonths. 2 From the 415 children, we recruited 16 chronically infected gen antibody; HBV, hepatitis B virus; PCR, polymerase chain reaction; PBMC, peripheral children who had cleared serum HBsAg for more than 2 years. After blood mononuclear cells; rHBsAg, recombinant hepatitis B surface antigen; PHA, phytoheobtaining informed consent from the patients and/or their parents, magglutinin; IL, interleukin; SI, stimulation index; cpm, counts per minute; IFN-g, interwe studied their immune response to HBsAg. There were 10 boys feron gamma; S/N, sample cpm per negative control mean cpm; Th, T helper cell.

From the Departments of 1 Emergency Medicine, 2 Pediatrics, and 3 Laboratory Medicine, and 6 girls, with a mean age of 14.4 years (range, 8-20 years). Of College of Medicine, National Taiwan University and 4 Development Center for Biotechnol-the 16, 11 patients did not develop anti-HBs during the follow-up ogy, Taipei, Taiwan. period of at least 2 years from the time HBsAg disappeared (group