Evidence suggests that endothelial cell layer heparan sulfate proteoglycans include a variety of different sized molecules which most likely contain different protein cores. In the present report, approximately half of endothelial cell surface associated heparan sulfate proteoglycan is shown to be r
Heparin induces changes in the synthesis of porcine aortic endothelial cell heparan sulfate proteoglycans
β Scribed by Peter Morrison; Linda J. Lowe-Krentz
- Book ID
- 115892409
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 786 KB
- Volume
- 184
- Category
- Article
- ISSN
- 0014-4827
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Heparin stimulates 2-3-fold, in a concentration-dependent manner, the synthesis of heparan sulfate secreted by cultured endothelial cells. The increase in synthetic rate takes place immediately after exposure of the cells to heparin, affects only heparan sulfate, and i s specific for the endothelial
## Abstract Exposure of endothelial cells to heparin and other antithrombotic drugs specifically stimulates the synthesis of an antithrombotic heparan sulfate (HS). In the present work, biotinylated heparin (BiotHep) was used to characterize the binding site(s) of heparin responsible for the stimul