Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy
✍ Scribed by Shingo Miyamoto; Hiroshi Yagi; Fusanori Yotsumoto; Tatsuhiko Kawarabayashi; Eisuke Mekada
- Book ID
- 108583626
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 335 KB
- Volume
- 97
- Category
- Article
- ISSN
- 1347-9032
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## Abstract ## BACKGROUND. Cleavage of membrane‐anchored heparin‐binding epidermal growth factor‐like growth factor (proHB‐EGF) yields a soluble HB‐EGF isoform (sHB‐EGF), which is an activating epidermal growth factor receptor (EGFR) ligand and a C‐terminal fragment HB‐EGF‐C acting directly in the
Several growth factors including hepatocyte growth factor (HGF) have been implicated in the regulation of liver regeneration. Recently, we reported that heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) has hepatotrophic effects in vitro. We investigated the role of HB-EGF as