𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Hemoglobin miyada: DNA analysis of the anti-lepore βδ fusion gene

✍ Scribed by Dr. M. Catherine Driscoll; Yoshiro Ohta; Frank Nakamura; Arthur Bloom; Arthur Bank

Book ID
101433746
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
490 KB
Volume
17
Category
Article
ISSN
0361-8609

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✦ Synopsis

Hemoglobin Miyada, an anti-Lepore hemoglobin, represents the protein product of a nonhomologous crossover between beta and delta genes. The mutant globin is beta-like from the N terminus to amino acid 12, and delta-like from amino acid 22 through the C terminus, thus predicting a crossover site in the first coding region of the gene. DNA analysis, using multiple restriction endonucleases and hybridization to delta and beta globin gene-specific probes, confirms that the beta delta hybrid gene 1) is located on a single chromosomal fragment between normal delta and beta genes, and 2) has 5' beta promoter sequences, delta IVS 1 and 2, and 3' coding and flanking sequences.

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