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Gene fusion of molecular adjuvant C3d to hCGβ enhances the anti-hCGβ antibody response in DNA immunization

✍ Scribed by Da-Jin Li; Hong-Mei Wang; Lei Li; Xin-Rong Zhao; Ming-Yan Wang; Ying Zhu; Yi Meng; Min-Min Yuan

Book ID
113752434
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
443 KB
Volume
60
Category
Article
ISSN
0165-0378

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Gene conjugation of molecular adjuvant C3d3 to hCGβ increased the anti-hCGβ Th2 and humoral immune response in DNA immunization
✍ Xiu-Li Wang; Xin-Rong Zhao; Min Yu; Min-Min Yuan; Xiao-Ying Yao; Da-Jin Li 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB

## Abstract Human chorionic gonadotropin (hCG) has been used as an anti‐fertility vaccine and as a target for cancer immunotherapy. We have explored the use of three copies of C3d in DNA vaccine as molecular adjuvant to improve the immunogenicity of this hormone in previous work and found that the