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A fusion gene in man: DNA sequence analysis of the abnormal globin gene of Hemoglobin Miyada

✍ Scribed by Akinori Kimura; Yoshiro Ohta; Yasuyuki Fukumaki; Yasuyuki Takagi


Book ID
115757643
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
815 KB
Volume
119
Category
Article
ISSN
0006-291X

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Hemoglobin miyada: DNA analysis of the a
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Hemoglobin Miyada, an anti-Lepore hemoglobin, represents the protein product of a nonhomologous crossover between beta and delta genes. The mutant globin is beta-like from the N terminus to amino acid 12, and delta-like from amino acid 22 through the C terminus, thus predicting a crossover site in t

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Nuclear DNA has been analyzed by means of restriction endonuclease mapping procedure to identify chromosomes that carry mutant Hb KΓΆln beta-globin genes in a family with individuals heterozygous for this disease. Inherited DNA polymorphisms within the beta-globin gene cluster yielded a direct linkag