Heme Oxygenase-1 Modulates Fetal Growth in the Rat
✍ Scribed by Kreiser, Doron; Nguyen, Xuandai; Wong, Ron; Seidman, Daniel; Stevenson, David; Quan, Shou; Abraham, Nader; Dennery, Phyllis A
- Book ID
- 110087084
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 909 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0023-6837
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## Abstract Glial heme oxygenase‐1 is over‐expressed in the CNS of subjects with Alzheimer disease (AD), Parkinson disease (PD) and multiple sclerosis (MS). Up‐regulation of HO‐1 in rat astroglia has been shown to facilitate iron sequestration by the mitochondrial compartment. To determine whether
## Abstract Heme oxygenase‐1 (HO‐1) catalyzes the degradation of heme to carbon monoxide (CO), iron, and biliverdin. Biliverdin is subsequently metabolized to bilirubin by the enzyme biliverdin reductase. Although interest in HO‐1 originally centered on its heme‐degrading function, recent findings