Heme oxygenase-1 expression in rats with acute lung rejection and implication
β Scribed by Ke Jiang; Lin Cheng; Jiangjun Wang; Jinsong Li; Jun Nie
- Book ID
- 107405890
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- Chinese
- Weight
- 594 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0510-9752
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Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme to biliverdin, carbon monoxide (CO), and free iron. The enzyme exists as a constitutive isoform (HO-2) and an inducible isoform (HO-1), which is also a stress protein (HSP32). HO-1 has previously been shown to be associated wi
Vascular heme oxygenase (HO) regulates vascular tone in normal conditions and in some pathologic circumstances (e.g., sepsis). However, its possible role in the pathogenesis of arterial vasodilation in cirrhosis is unknown. To address this question, the expression and activity of HO in arterial vess