Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist

✍ Scribed by Valerie I. Brown (eds.)

• Publisher: Springer International Publishing
• Year: 2018
• Tongue: English
• Leaves: 451
• Edition: 1
• Category: Library

✦ Synopsis

This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader.

Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.

✦ Table of Contents

Front Matter ....Pages i-xi
Front Matter ....Pages 1-1
Introduction (Valerie I. Brown)....Pages 3-5
Historical Overview of Pediatric HSCT (Valerie I. Brown)....Pages 7-18
Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT) (Valerie I. Brown)....Pages 19-53
Front Matter ....Pages 55-55
Pretransplantation: Indications and Timing (Alicia McFarren, Michael A. Pulsipher)....Pages 57-76
Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric Leukemia (Hisham Abdel-Azim, Michael A. Pulsipher)....Pages 77-90
HSCT Recipient Pretransplantation Evaluation (Carrie Eichelberger, Valerie I. Brown)....Pages 91-96
How to Select a Donor and Hematopoietic Stem Cell Source: Related Versus Unrelated Donors for Allogeneic HSCT (Malika Kapadia, Robert Greiner)....Pages 97-110
Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement, and Manipulation (William Ferguson, Aleksandar Babic)....Pages 111-138
Preparing the Patient for HSCT: Conditioning Regimens and Their Scientific Rationale (Carrie-Lynn Kitko, Katie Gatwood, James Connelly)....Pages 139-174
Front Matter ....Pages 175-175
Engraftment and Chimerism (Valerie I. Brown)....Pages 177-186
Graft Failure (Valerie I. Brown)....Pages 187-194
Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome (Mala K. Talekar, Jason L. Freedman)....Pages 195-199
Nutrition in the Peri-HSCT Period (Arun Gurunathan, Judy Bailer, Jason L. Freedman)....Pages 201-207
Mucositis and Pain in the Peri-HSCT Period (Arun Gurunathan, Neil S. Patel, Jason L. Freedman)....Pages 209-214
Hepatotoxicity in the Peri-HSCT Period (Valerie I. Brown)....Pages 215-233
Renal Toxicities in the Peri-HSCT Period (Malika Kapadia, Terry Wikle Shapiro, Robert Greiner)....Pages 235-240
Infectious Complications and HSCT (Karen L. Bride, Ellen Levy, Anne Wohlschlaeger, Jason L. Freedman)....Pages 241-255
Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and Treatment (Karen L. Bride, Neil S. Patel, Jason L. Freedman)....Pages 257-265
Front Matter ....Pages 267-267
Chronic GvHD (Terry Wikle Shapiro, Malika Kapadia)....Pages 269-282
Hematologic Complications Associated with HSCT (Mala K. Talekar, Timothy Olson)....Pages 283-299
Pulmonary Complications Associated with HSCT (Malika Kapadia, Terry Wikle Shapiro)....Pages 301-325
Renal Complications Associated with HSCT (Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin)....Pages 327-332
Cardiac Complications Associated with HSCT (Valerie I. Brown)....Pages 333-341
Neurologic and Sensory Complications Associated with HSCT (Valerie I. Brown)....Pages 343-361
HSCT-Associated Complications of the Skin, Hair, and Nails (Valerie I. Brown)....Pages 363-368
Front Matter ....Pages 369-369
Immune Reconstitution After Hematopoietic Stem Cell Transplantation (Mala K. Talekar, Timothy Olson)....Pages 371-383
Life After HSCT: Survivorship and Long-Term Issues (Smita Dandekar)....Pages 385-401
Front Matter ....Pages 403-403
Medications Commonly Used in Pediatric HSCT (Kevin M. Mulieri, Ashley Teusink-Cross, JoEllen Weilnau, Krisoula Spatz, Katie S. Gatwood)....Pages 405-448
Back Matter ....Pages 449-460

✦ Subjects

Hematology