HELPER SIGNALS IN T-T CELL COLLABORATION
✍ Scribed by Janet Plate†
- Book ID
- 118717769
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 356 KB
- Volume
- 332
- Category
- Article
- ISSN
- 0890-6564
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Cytotoxic T lymphocytes are major effector cells in responses to viral infections and in allograft rejection and are implicated in many other immunological reactions. Efficient induction of cytotoxic activity in these cells in many but not all cases depends upon helper Tand antigen-presenting cells
B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once ac