T helper cells

✍ Scribed by Randolph Noelle; E.Charles Snow

• Book ID: 103972896
• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 696 KB
• Volume: 4
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(92)90085-s

✦ Synopsis

B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.