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Helix–coil transition in heterogeneous chains. II. DNA model

✍ Scribed by B. K. Eichinger; M. Fixman

Publisher
Wiley (John Wiley & Sons)
Year
1970
Tongue
English
Weight
843 KB
Volume
9
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Melting curves are calculated for infinitely long DNA‐like random copolymers composed of AT and GC pairs of nucleotides. The entropy of random coil rings formed on melting is explicitly included through use of the Jacobson‐Stockmayer ring‐weighting factors. Transition curves are calculated for values of the cooperativity parameter σ in the range 10^−2^ ⩽ σ ⩽ 10^−4^. Ninety percent of the melting occurs in ca. 0.2°C for σ ⩽ 10^−3^ regardless of the mole fraction of GC. We conclude that observed breadths of thermal denaturation curves for native DNAs result from a superposition of essentially all‐or‐none melting of various regions of the molecule. It is argued that refined approximations to the ring‐weighting factors are probably not important when compared with the effects produced by long‐range base sequence correlations which are known to occur in native DNA.

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## Abstract Equilibrium properties of heterogeneous DNA near the melting temperature __T__~__m__~ are investigated using the grand partition function. The present approach gives exact and analytical solutions. The algebraic expressions enhance a more thorough understanding of the correlation among