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Heat induces gene amplification in cancer cells

✍ Scribed by Bin Yan; Ruoyun Ouyang; Chenghui Huang; Franklin Liu; Daniel Neill; Chuanyuan Li; Mark Dewhirst


Book ID
119194563
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
394 KB
Volume
427
Category
Article
ISSN
0006-291X

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In an attempt to study the regulatory properties of cells required for gene amplification, the capacity for amplification of the dehydrofolate reductase gene (dhfr) was determined in F9 teratocarcinoma stem cells during differentiation. By stepwise selection of surviving cells exposed to progressive