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Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance

โœ Scribed by Nami Yabuki; Kiyoaki Sakata; Tomoaki Yamasaki; Hiromichi Terashima; Toshiyuki Mio; Youko Miyazaki; Toshihiko Fujii; Kunio Kitada


Book ID
113513020
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
819 KB
Volume
173
Category
Article
ISSN
0165-4608

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HER2 is an erbB/HER type 1 tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined wi