Human non-small-cell lung cancer (NSCLC) is considered to be a chemotherapy-refractory malignancy. The underlying mechanisms remain rather obscure. The multidrug resistanceassociated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several dru
The association of increased lung resistance protein expression with acquired etoposide resistance in human H460 lung cancer cell lines
β Scribed by Eunmyong Lee; Soo-Jeong Lim
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 657 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0253-6269
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Annamycin (Ann) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo. A liposomal formulation of Ann is currently in phase I clinical trials. The multidrug resistance-associated protein (MRP) has been found to be over-expressed in some hum
Multidrug resistance (MDR) in human cancer cells is multifactorial. Previously, we reported on the association between expression of P-glycoprotein (Pgp), the multidrug resistanceassociated protein (MRP), and the lung resistance protein (LRP) with the MDR phenotype in the NCI panel of 60 human cance