Human non-small-cell lung cancer (NSCLC) is considered to be a chemotherapy-refractory malignancy. The underlying mechanisms remain rather obscure. The multidrug resistanceassociated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several dru
โฆ LIBER โฆ
A novel quinoline derivative, MS-209, overcomes drug resistance of human lung cancer cells expressing the multidrug resistance-associated protein (MRP) gene
โ Scribed by Fumihiko Narasaki; Mikio Oka; Minoru Fukuda; Reiji Nakano; Koki Ikeda; Hiroshi Takatani; Kenji Terashi; Hiroshi Soda; Osamu Yano; Tsuyoshi Nakamura; L. Austin Doyle; Takashi Tsuruo; Shigeru Kohno
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 278 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0344-5704
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MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expres- sion of M R P mRNA in multidrug-resistant KB sublines (KB-8-5, KB-CZ, C -W and C A I to), human non-small-cell lung carcinomas (NSC