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Circumvention of multidrug resistance by a quinoline derivative, MS-209, in multidrug-resistant human small-cell lung cancer cells and its synergistic interaction with cyclosporin A or verapamil

✍ Scribed by Punya Shrivastava; Masaki Hanibuchi; Seiji Yano; Prahlad Parajuli; Takashi Tsuruo; Saburo Sone


Publisher
Springer
Year
1998
Tongue
English
Weight
194 KB
Volume
42
Category
Article
ISSN
0344-5704

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## Abstract A doxorubicin‐resistant variant of the human small‐cell lung‐cancer cell line N592 was selected by __in vitro__ continuous exposure to increasing drug concentrations. The aim of this study was to examine the cross‐resistance pattern, cellular pharmacokinetics of doxorubicin and expressi