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Head and neck paragangliomas

✍ Scribed by Mendenhall, William M. (author);Amdur, Robert J. (author);Vaysberg, Mikhail (author);Mendenhall, Charles M. (author);Werning, John W. (author)

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
79 KB
Volume
33
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

The purpose of this study was to describe the natural history and optimal treatment for head and neck paragangliomas (PGs).

Methods

Our methods were the review of the pertinent literature.

Results

PGs are rare tumors seen most commonly in the head and neck. Approximately 90% are sporadic; the remainder are familial and related to mutations of the succinate dehydrogenase (SDH) gene complex. Most PGs are benign and slow growing; 6% to 19% are malignant, as evidenced by the development of metastases. PGs may be treated by complete resection or moderate‐dose radiotherapy with a β‰₯90% likelihood of cure. The optimal radiotherapy dose is approximately 45 Gy/25 fractions/5 weeks. The treatment modality selected depends on the risk of complications. Due to their rarity, the optimal treatment for malignant PGs is unclear.

Conclusion

PGs may be treated by either complete resection or radiotherapy with a high likelihood of success. Treatment depends on the location and extent of the PG and the morbidity associated with treatment. Β© 2010 Wiley Periodicals, Inc. Head Neck, 2010

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