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Management of head and neck paragangliomas: Review of 120 patients

✍ Scribed by Konstantinos Papaspyrou; Wolf J. Mann; Ronald G. Amedee

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 98 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20967

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✦ Synopsis

Abstract

Background.

Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally.

Methods and Results.

A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included. The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 92% of JTT and 88% of TT resections.

Conclusion.

According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically. © 2008 Wiley Periodicals, Inc. Head Neck, 2009

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