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Definitive radiotherapy in the management of paragangliomas arising in the head and neck: A 35-year experience

✍ Scribed by Russell W. Hinerman; Robert J. Amdur; Christopher G. Morris; Jessica Kirwan; William M. Mendenhall

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
122 KB
Volume
30
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

An evaluation of the treatment results for 104 patients with 121 paragangliomas of the temporal bone, carotid body, and/or glomus vagale who were treated with radiation therapy (RT) at the University of Florida between 1968 and 2004.

Methods.

Eighty‐nine paragangliomas (86%) were treated with conventional megavoltage techniques, 15 (14%) patients with stereotactic fractionated radiation therapy, 6 (6%) patients with stereotactic radiosurgery (SRS), and 11 (11%) patients with intensity‐modulated radiation therapy (IMRT).

Results.

There were 6 local recurrences. One recurrence was salvaged with additional RT. The actuarial local control and cause‐specific survival rates at 10 years were 94% and 95%. The overall local control rate for all 121 lesions was 95%; the ultimate local control rate was 96%. The incidence of treatment‐related complications was low.

Conclusion.

Fractionated RT offers a high probability of tumor control with minimal risks for patients with paragangliomas of the temporal bone and neck. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

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