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Management of the neck in a randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer

✍ Scribed by Pierre Lavertu; David J. Adelstein; Jerrold P. Saxton; Michelle Secic; John R. Wanamaker; Isaac Eliachar; Benjamin G. Wood; Marshall Strome

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
94 KB
Volume
19
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Treating the neck after organpreservation treatment with radiotherapy or chemoradiotherapy can be problematic.

Methods. To develop management guidelines, we reviewed the results of a 100-patient phase-3 trial that had compared outcome after radiotherapy alone with outcome after chemoradiotherapy for head and neck cancer. Patients were randomly assigned to receive radiotherapy alone or concurrent chemoradiotherapy. After completing therapy, patients were reassessed, and surgery was recommended for persistent disease at the primary site or neck and for all patients with stage N2-3 neck nodes regardless of clinical response.

Results. Of the 47 patients with stage N0-1, 43 had a complete response (CR); of the 18 N1 patients, all but 4 had a CR.

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