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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

✍ Scribed by Watanabe, Norihiko; Wang, Yi-Hong; Lee, Heung Kyu; Ito, Tomoki; Wang, Yui-Hsi; Cao, Wei; Liu, Yong-Jun


Book ID
109894588
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
345 KB
Volume
436
Category
Article
ISSN
0028-0836

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## Abstract We have previously shown that human monocyte‐derived dendritic cells (DC) express indoleamine 2,3‐dioxygenase (IDO), as well as several other enzymes of the kynurenine pathway at the mRNA level upon maturation. The tolerogenic mechanisms of this pathway remain unclear. Here we show that