Immunomodulatory drug FTY720 induces regulatory CD4+CD25+ T cells in vitro
β Scribed by P. J. Zhou; H. Wang; G. H. Shi; X. H. Wang; Z. J. Shen; D. Xu
- Book ID
- 108701040
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 288 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0009-9104
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We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixt
## Abstract Interleukinβ2 (ILβ2) treatment is currently used to enhance T cellβmediated immune responses against tumors or in viral infections. At the same time, ILβ2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that ILβ2 is a