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HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway

✍ Scribed by Rosalba Serù; Paolo Mondola; Simona Damiano; Silvia Svegliati; Savina Agnese; Enrico V. Avvedimento; Mariarosaria Santillo

Book ID: 111178529
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 257 KB
Volume: 91
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2004.02754.x

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## Abstract Overexpression of cyclooxygenase‐2 (COX‐2) and elevation of its derivative prostaglandin E~2~ (PGE~2~) are implicated in human esophageal squamous cell carcinoma. The expression of c‐Myc, an oncogenic transcription factor, is also upregulated in this malignant disease. This study sought