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Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway

โœ Scribed by Craig A. Simmons; Sean Matlis; Amanda J. Thornton; Shaoqiong Chen; Cun-Yu Wang; David J. Mooney


Book ID
108333147
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
491 KB
Volume
36
Category
Article
ISSN
0021-9290

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi