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Haplotype analysis of the fragile X syndrome geneFMR1 in the Czech Republic

✍ Scribed by Pekar�k, Vladim�r; Blazkov�, Michaela; Koz�k, Libor

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
5 KB
Volume
84
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19990528)84:3<214::aid-ajmg9>3.0.co;2-a

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✦ Synopsis

We report on the haplotype analysis with polymorphic repeat markers DXS548 and FRAXAC1 next to the FMR1 gene in 37 unrelated fragile X and 36 control chromosomes from Bohemia and Moravia. Our results suggest a significant linkage disequilibrium between fragile X mutations and certain DXS548-FRAXAC1 haplotypes. Allele frequencies obtained differ slightly from those of other European populations with allele 194 being less frequent in our control sample. Rare DXS548 alleles 6.5 (195) and 0 (208) were also present. Am.

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