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Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

โœ Scribed by Gutmann, David H; Loehr, Allison; Zhang, Yujing; Kim, Joanna; Henkemeyer, Mark; Cashen, Amanda


Book ID
110062244
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
725 KB
Volume
18
Category
Article
ISSN
0950-9232

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โœ M.J. Giordano; D.K. Mahadeo; Y.Y. He; R.T. Geist; C. Hsu; D.H. Gutmann ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 813 KB

Tumor suppressor genes encode proteins involved in growth regulation in differentiating and proliferating cells. Previous work from our laboratory has demonstrated that the neurofibromatosis 1 (NF1) tumor suppressor gene is dramatically upregulated in astrocytes stimulated with dibutyryl cyclic AMP