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Halogenolactamization of 2-(3-Butenyl)-1,3-oxazolines to Bifunctional γ- and δ-Lactams

✍ Scribed by Keiji Terao; Yumiko Takechi; Munetaka Kunishima; Shohei Tani; Akiko Ito; Chisa Yamasaki; Shin-ichi Fukuzawa


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
33
Category
Article
ISSN
0931-7597

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NaBH4-I2 mediated chemoselective reducti
✍ Gopa Barman; Pranab Haldar; Neelanjan Dutta; Jayanta K. Ray 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 94 KB

Substituted pyrrolidine derivatives were synthesized in high yield by NaBH 4 /I 2 mediated chemoselective reduction of N-aryl-c-lactam and N-aryl-thio-c-lactam-2,2-dicarboxylate. With excess NaBH 4 /I 2 , carbonyl functionality of the ester groups remained unchanged.