NaBH4-I2 mediated chemoselective reduction of γ-lactam and thio-γ-lactam in presence of gem-dicarboxylates: An easy access to 1,3-diaryl pyrrolidines

✍ Scribed by Gopa Barman; Pranab Haldar; Neelanjan Dutta; Jayanta K. Ray

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 94 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.542

✦ Synopsis

Substituted pyrrolidine derivatives were synthesized in high yield by NaBH 4 /I 2 mediated chemoselective reduction of N-aryl-c-lactam and N-aryl-thio-c-lactam-2,2-dicarboxylate. With excess NaBH 4 /I 2 , carbonyl functionality of the ester groups remained unchanged.