ChemInform Abstract: NaBH4—I2 Mediated Chemoselective Reduction of γ-Lactam and Thio-γ-lactam in Presence of Gem-dicarboxylates: An Easy Access to 1,3-Diaryl Pyrrolidines.

NaBH4-I2 mediated chemoselective reducti

NaBH4-I2 mediated chemoselective reduction of γ-lactam and thio-γ-lactam in presence of gem-dicarboxylates: An easy access to 1,3-diaryl pyrrolidines

✍ Gopa Barman; Pranab Haldar; Neelanjan Dutta; Jayanta K. Ray 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 94 KB 👁 1 views

Substituted pyrrolidine derivatives were synthesized in high yield by NaBH 4 /I 2 mediated chemoselective reduction of N-aryl-c-lactam and N-aryl-thio-c-lactam-2,2-dicarboxylate. With excess NaBH 4 /I 2 , carbonyl functionality of the ester groups remained unchanged.