## Abstract The syntheses of N‐substituted 1‐O‐alkyl‐2‐desoxy‐2‐amino‐__sn__‐glycero‐3‐[^32^P]phosphocholines were performed in four steps starting from [^32^P] POCl~3~ and the corresponding 1‐O‐alkyl‐2‐amino‐propane‐3‐ols in 5‐7% total yield.
Halo lipids, 8. Synthesis of O-alkyl-O-alkyl-O-(2,2,2-trifluoroethyl)glycerols and O-alkyl-O-(2,2,2-trifluoroethyl)glycero-phosphocholines
✍ Scribed by H. Brachwitz; P. Franke; R. Hintsche; P. Langen; J. Schildt
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 805 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
The syntheses and structure determination of 3 positional isomers of O-alkyl-O-(2,2,2-trilluoroethyl)glycerols and their conversion into the corresponding O-alkyl-O-(2,2,2-tritluoroethyl)glycerophosphocholines via the [O-alkyl-O-(2,2,2-trifluoroethyl)~ycero]-2-bromoethyl hydrogen phosphates are described.
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Racemic l-O-(2-methyloctadecyl)-2-O-acetyl-glycero-3-phosphocholine, a branched chain PAF species, was prepared by chemical synthesis and investigated for biological activity on human blood platelets in vitro. The synthesis started from 2-O-benzylglycerol and 2-methyloctadecyl-l-methyl sulfonate and
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