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Halo lipids. 7. Synthesis of rac 1-chloro-1-deoxy-2-O-hexadecylglycero-3-phosphocholine

✍ Scribed by H. Brachwitz; P. Langen; J. Schildt

Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
364 KB
Volume
34
Category
Article
ISSN
0009-3084

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✦ Synopsis

In order to obtain detailed data on the structure-activity relationship of cytostatically active alkylglycerophosphocholine analogues, rac l-chloro-l-deoxy-2-O-hexadecylglycero-3-phosphocholine was synthesised via 2-O-alkyl-l-chloro-l-deoxyglycerol and (2-O-alkyl-l-chloro-ldeoxyglycero-3)-2-bromoethyl hydrogen phosphate.

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