Guanine-Containing DNA Minor-Groove Binders

✍ Scribed by Daniel Pulido; Albert Sánchez; Jordi Robles; Enrique Pedroso; Anna Grandas

• Book ID: 102176068
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 361 KB
• Volume: 2009
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200800892

✦ Synopsis

Abstract

Solid‐phase procedures have been used to prepare six dipyrrole‐containing DNA ligands that combine (guanin‐9‐yl)acetyl, (guanin‐7‐yl)acetyl or acetyl moieties at the N‐terminal end and two lysines or a (dimethylamino)propyl group at the C terminus. Inspection of their DNA‐stabilizing properties by UV‐monitored thermal denaturation experiments showed that the ligand incorporating the (guanin‐9‐yl)acetyl group and the (dimethylamino)propyl tail had the highest duplex‐stabilizing effects.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)