A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to c
β¦ LIBER β¦
Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions
β Scribed by Legin, Anton A.; Jakupec, Michael A.; Bokach, Nadezhda A.; Tyan, Marina R.; Kukushkin, Vadim Yu.; Keppler, Bernhard K.
- Book ID
- 121470338
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 616 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0162-0134
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