✦ LIBER ✦

GTPases in antigen receptor signalling

✍ Scribed by Stefan W Henning; Doreen A Cantrell

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 785 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80171-4

No coin nor oath required. For personal study only.

✦ Synopsis

Immunological interest in small GTPases has focused for some years almost exclusively on the role of Ras in promoting lymphocyte activation and development. A new concept in this field is that GTPases are linked to multiple biochemical effector signalling pathways and are consequently able to regulate diverse cellular processes. It is also now recognised that GTPases other than Ras regulate lymphocyte biology. Rap 1 has been suggested as a negative regulator of lymphocyte responses and Rho GTPases are important components of signalling pathways used by antigen receptors and by costimulatory, cytokine and chemokine receptors to regulate the immune response.

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