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Adaptor proteins in lymphocyte antigen-receptor signaling

✍ Scribed by Erik J Peterson; James L Clements; Nan Fang; Gary A Koretzky

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
730 KB
Volume
10
Category
Article
ISSN
0952-7915

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✦ Synopsis

Adaptor molecules, proteins that possess no intrinsic enzymatic function, but which mediate protein-protein interactions, have a critical role in integrating signal transduction pathways following engagement of cell-surface receptors. Several newly described adaptor molecules have been shown to serve important functions in the regulation of signaling events initiated by lymphocyte antigen receptors. Understanding how these adaptor proteins function to modulate signaling cascades will provide important insights into the complex biology of lymphocyte activation.

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